Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications
نویسندگان
چکیده
منابع مشابه
Cell-penetrating peptides and their therapeutic applications
The process of introducing drugs into cells has always proved a major challenge for research scientists and for the pharmaceutical industry. The cell membrane is selectively permeable and supports no generic mechanism for their uptake. A drug must be either highly lipophilic or very small to stand a chance of cellular internalization. These restrictions mean that the repertoire of possible drug...
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Regulation of biological processes through the use of genetic elements is a central part of biological research and also holds great promise for future therapeutic applications. Oligonucleotides comprise a class of versatile biomolecules capable of modulating gene regulation. Gene therapy, the concept of introducing genetic elements in order to treat disease, presents a promising therapeutic st...
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Cell-penetrating peptides (CPPs) mediate the uptake of interconnected cargoes of different types into cells and organisms. Studies in living cells revealed that high-molecular-weight cargoes linked to CPPs are delivered via endocytic routes whereas CPPs by themselves or fused to low-molecular-weight cargoes can in addition enter by a mechanism that does not require vesicle formation. This latte...
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Protein transduction domains (PTDs), both naturally occurring and synthetic, have been increasingly employed to deliver biologically active agents to a variety of cell types in vitro and in vivo. In addition to the previously characterized arginine-rich PTDs, including Tat (transactivator of transcription), Antp (Antennapedia) and PTD-5, we have demonstrated that lysine and ornithine, as well a...
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Potential antimicrobial agents may be effective if they are delivered efficiently to their site of action. In many cases, lack of permeability through the cell membrane is the main problem. One of the possible solutions could be a novel intracellular delivery system involving cell-penetrating peptides (CPPs), which may improve the efficiency of many new biopharmaceuticals. Among other things, C...
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ژورنال
عنوان ژورنال: Biomedical Reports
سال: 2016
ISSN: 2049-9434,2049-9442
DOI: 10.3892/br.2016.639